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KMID : 0355420160400020079
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Journal of Korean Academy of Oral Health
2016 Volume.40 No. 2 p.79 ~ p.84
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Gingival absorption of α-tocopherol acetate and 18β-glycyrrhetinic acid : in vitro evaluationin reconstructed gingival tissue
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Kim Yun-Sun
Kim Ju-Ae
You A-Ram
Cho Ho-Song
Shin Jae-Young
Lee Sang-Hwa
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Abstract
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Objectives: To assess the absorption of α-tocopherol acetate and 18β-glycyrrhetinic acid, which are used as active ingredients in toothpaste, into a reconstructed gingival tissue.
Methods: EpiGingivalTM tissues were treated with a 25% slurry of toothpaste containing 2% α-tocopherol acetate and 0.3% 18β-glycyrrhetinic acid, for 2 minutes. The treatment was repeated up to 6 times, with 1 hour intervals. After completion of all treatments, the active ingredients in the tissue extracts and receiver solutions were measured by high performance liquid chromatography.
Results: Although α-tocopherol acetate was not detected, α-tocopherol was detected in the tissue extracts, indicating that α-tocopherol acetate was bioconverted to α-tocopherol after absorption. We could detect 18β-glycyrrhetinic acid both in the tissue extracts and in the receiver solutions, with a posi-tive correlation to the number of treatments.
Conclusions: We found that our toothpaste effectively delivered α-tocopherol acetate and 18β-glycyrrhetinic acid to a reconstructed gingival tissue in vitro.
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KEYWORD
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Absorption, α-Tocopherol acetate, 18β-Glycyrrhetinic acid, Periodontal disease, Toothpaste
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